Query Result:

Summary: help

Your query was: P34058    
1
724

Domain annotation: [ InterPro ]

Colors:    Query |  Sequence |  Structures |  Models  |  Domains   |    

P34058 HS90B_RAT ; Heat shock protein HSP 90-beta; Heat shock 84 kDa; HSP 84; HSP84; Rattus norvegicus (Rat).

  

Models:

Model
 
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Sel.
[Show] reliability_1
SWISSMODEL
SC 3pryA
96% 284 546
[Show] reliability_1
MODBASE
SC 1byqA
92% 7 218
[Show] reliability_1
SWISSMODEL
SC 3q6mB
81% 286 691
[Show] reliability_1
SWISSMODEL
SC 2cg9B
58% 13 688
[Show] reliability_3
NYSGXRC
TC 3cwvA
11% 45 453

Experimental Structures:

PDB Description %Seq Id from - to Sel.
3pryCrystal structure of the middle domain of human HSP90-beta refined at 2.3 A resolution
99 284-546   
3nmqHsp90b N-terminal domain in complex with EC44, a pyrrolo-pyrimidine methoxypyridine inhibitor
100 1-223   
1uymHUMAN HSP90-BETA WITH PU3 (9-BUTYL-8(3,4,5-TRIMETHOXY-BENZYL)-9H-PURIN-6-YLAMINE)
100 2-221   
3whaHsp90 alpha N-terminal domain in complex with a tricyclic inhibitor
92 9-231   
3vhdHsp90 alpha N-terminal domain in complex with a macrocyclic inhibitor, CH5164840
92 9-231   
3vhcHsp90 alpha N-terminal domain in complex with a macrocyclic inhibitor
92 9-231   
3vhaHsp90 alpha N-terminal domain in complex with a macrocyclic inhibitor
92 9-231   
3b28Hsp90 alpha N-terminal domain in complex with an inhibitor CH5015765
92 9-231   
3b27Hsp90 alpha N-terminal domain in complex with an inhibitor Ro4919127
92 9-231   
3b26Hsp90 alpha N-terminal domain in complex with an inhibitor Ro1127850
92 9-231   
3b25Hsp90 alpha N-terminal domain in complex with an inhibitor CH4675194
92 9-231   
3b24Hsp90 alpha N-terminal domain in complex with an aminotriazine fragment molecule
92 9-231   
3rkzDiscovery of a stable macrocyclic o-aminobenzamide Hsp90 inhibitor capable of significantly decreasing tumor volume in a mouse xenograft model.
92 9-231   
3r92Discovery of a macrocyclic o-aminobenzamide Hsp90 inhibitor with heterocyclic tether that shows extended biomarker activity and in vivo efficacy in a mouse xenograft model.
92 9-231   
3r91Macrocyclic lactams as potent Hsp90 inhibitors with excellent tumor exposure and extended biomarker activity.
92 9-231   
3qtfDesign and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity
92 9-231   
3bmyDiscovery of Benzisoxazoles as Potent Inhibitors of Chaperone Hsp90
92 9-231   
3bm9Discovery of Benzisoxazoles as Potent Inhibitors of Chaperone Hsp90
92 9-231   
2bz5STRUCTURE-BASED DISCOVERY OF A NEW CLASS OF HSP90 INHIBITORS
92 9-231   
2byi3-(5-CHLORO-2,4-DIHYDROXYPHENYL)-PYRAZOLE-4-CARBOXAMIDES AS INHIBITORS OF THE HSP90 MOLECULAR CHAPERONE
92 9-231   
2byh3-(5-CHLORO-2,4-DIHYDROXYPHENYL)-PYRAZOLE-4-CARBOXAMIDES AS INHIBITORS OF THE HSP90 MOLECULAR CHAPERONE
92 9-231   
2bt0NOVEL, POTENT SMALL MOLECULE INHIBITORS OF THE MOLECULAR CHAPERONE HSP90 DISCOVERED THROUGH STRUCTURE-BASED DESIGN
92 9-231   
2bsmNOVEL, POTENT SMALL MOLECULE INHIBITORS OF THE MOLECULAR CHAPERONE HSP90 DISCOVERED THROUGH STRUCTURE-BASED DESIGN
92 9-231   
4egkHuman Hsp90-alpha ATPase domain bound to Radicicol
92 9-231   
4egiHsp90-alpha ATPase domain in complex with 2-Amino-4-ethylthio-6-methyl-1,3,5-triazine
92 9-231   
4eghHsp90-alpha ATPase domain in complex with (4-Hydroxyphenyl)morpholin-4-yl methanone
92 9-231   
3inxHSP90 N-TERMINAL DOMAIN with pochoxime B
92 9-231   
3inwHSP90 N-TERMINAL DOMAIN with pochoxime A
92 9-231   
4awqComplex of HSP90 ATPase domain with tropane derived inhibitors
92 9-231   
4awpComplex of HSP90 ATPase domain with tropane derived inhibitors
92 9-231   
4awoComplex of HSP90 ATPase domain with tropane derived inhibitors
92 9-231   
4o0bIdentification of novel HSP90/isoform selective inhibitors using structure-based drug design. Demonstration of potential utility in treating CNS disorders such as Huntington's disease
92 9-231   
4o09Identification of novel HSP90 / isoform selective inhibitors using structure-based drug design. Demonstration of potential utility in treating CNS disorders such as Huntington s disease
92 9-231   
4o07Identification of novel HSP90/isoform selective inhibitors using structure-based drug design. Demonstration of potential utility in treating CNS disorders such as Huntington's disease
92 9-231   
4o05Identification of novel HSP90/isoform selective inhibitors using structure-based drug design. Demonstration of potential utility in treating CNS disorders such as Huntington's disease
92 9-231   
4nh8Correlation between chemotype-dependent binding conformations of HSP90 alpha/beta and isoform selectivity
92 9-231   
4nh7Correlation between chemotype-dependent binding conformations of HSP90 alpha/beta and isoform selectivity
92 9-231   
2yehHSP90 INHIBITORS AND DRUGS FROM FRAGMENT AND VIRTUAL SCREENING
92 9-231   
2yegHSP90 INHIBITORS AND DRUGS FROM FRAGMENT AND VIRTUAL SCREENING
92 9-231   
2yefHSP90 INHIBITORS AND DRUGS FROM FRAGMENT AND VIRTUAL SCREENING
92 9-231   
2yedHSP90 INHIBITORS AND DRUGS FROM FRAGMENT AND VIRTUAL SCREENING
92 9-231   
2yecHSP90 INHIBITORS AND DRUGS FROM FRAGMENT AND VIRTUAL SCREENING
92 9-231   
2yebHSP90 INHIBITORS AND DRUGS FROM FRAGMENT AND VIRTUAL SCREENING
92 9-231   
2yeaHSP90 INHIBITORS AND DRUGS FROM FRAGMENT AND VIRTUAL SCREENING
92 9-231   
2ye9HSP90 INHIBITORS AND DRUGS FROM FRAGMENT AND VIRTUAL SCREENING
92 9-231   
2ye6HSP90 INHIBITORS AND DRUGS FROM FRAGMENT AND VIRTUAL SCREENING
92 9-231   
2ye5HSP90 INHIBITORS AND DRUGS FROM FRAGMENT AND VIRTUAL SCREENING
92 9-231   
2ye4HSP90 INHIBITORS AND DRUGS FROM FRAGMENT AND VIRTUAL SCREENING
92 9-231   
2ye3HSP90 INHIBITORS AND DRUGS FROM FRAGMENT AND VIRTUAL SCREENING
92 9-231   
2ye2HSP90 INHIBITORS AND DRUGS FROM FRAGMENT AND VIRTUAL SCREENING
92 9-231   
4l94Crystal structure of Human Hsp90 with S46
92 9-231   
4l93Crystal structure of Human Hsp90 with S36
92 9-231   
4l91Crystal structure of Human Hsp90 with X29
92 9-231   
4l90Crystal structure of Human Hsp90 with RL3
92 9-231   
4l8zCrystal structure of Human Hsp90 with RL1
92 9-231   
4hy6Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ1
92 9-231   
3t2sHSP90 N-terminal domain bound to AGS
92 9-231   
3t1kHSP90 N-terminal domain bound to ANP
92 9-231   
3t10HSP90 N-terminal domain bound to ACP
92 9-231   
3t0zHsp90 N-terminal domain bound to ATP
92 9-231   
3t0hStructure insights into mechanisms of ATP hydrolysis and the activation of human Hsp90
92 9-231   
3r4mOptimization of Potent, Selective, and Orally Bioavailable Pyrrolodinopyrimidine-containing Inhibitors of Heat Shock Protein 90. Identification of Development Candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide
92 9-231   
4efuHsp90 Alpha N-terminal Domain in Complex with an Inhibitor 6-Hydroxy-3-(3-methyl-benzyl)-1H-indazole-5-carboxylic acid benzyl-methyl-amide
92 9-231   
4eftHsp90 Alpha N-terminal Domain in Complex with an Inhibitor 3-Cyclohexyl-2-(6-hydroxy-1H-indazol-3-yl)-propionitrile
92 9-231   
4eehHsp90 Alpha N-terminal Domain in Complex with an Inhibitor 3-(4-Hydroxy-phenyl)-1H-indazol-6-ol
92 9-231   
3k97HSP90 N-terminal domain in complex with 4-chloro-6-{[(2R)-2-(2-methylphenyl)pyrrolidin-1-yl]carbonyl}benzene-1,3-diol
92 9-231   
1yc4Crystal structure of human HSP90alpha complexed with dihydroxyphenylpyrazoles
91 9-231   
1yc3Crystal Structure of human HSP90alpha complexed with dihydroxyphenylpyrazoles
91 9-231   
1yc1Crystal Structures of human HSP90alpha complexed with dihydroxyphenylpyrazoles
91 9-231   
4jqlSynthesis of Benzoquinone-Ansamycin-Inspired Macrocyclic Lactams from Shikimic Acid
92 9-231   
3hz5Crystal structure of Hsp90 with fragment Z064
92 9-231   
3hz1Crystal structure of Hsp90 with fragments 37-D04 and 42-C03
92 9-231   
3hyzCrystal structure of Hsp90 with fragment 42-C03
92 9-231   
3hyyCrystal structure of Hsp90 with fragment 37-D04
92 9-231   
3ft8Structure of HSP90 bound with a noval fragment.
92 9-231   
3ft5Structure of HSP90 bound with a novel fragment
92 9-231   
2xk2Structure of HSP90 with small molecule inhibitor bound
92 9-231   
2xjxStructure of HSP90 with small molecule inhibitor bound
92 9-231   
2xhtSTRUCTURE OF HSP90 WITH SMALL MOLECULE INHIBITOR BOUND
92 9-231   
2xhrSTRUCTURE OF HSP90 WITH SMALL MOLECULE INHIBITOR BOUND
92 9-231   
2xdxSTRUCTRE OF HSP90 WITH SMALL MOLECULE INHIBITOR BOUND
92 9-231   
2xdsStructure of HSP90 with small molecule inhibitor bound
92 9-231   
2xdlSTRUCTURE OF HSP90 WITH SMALL MOLECULE INHIBITOR BOUND
92 9-231   
2xdkSTRUCTURE OF HSP90 WITH SMALL MOLECULE INHIBITOR BOUND
92 9-231   
2xabSTRUCTURE OF HSP90 WITH AN INHIBITOR BOUND
92 9-231   
4cwtHuman HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor
92 9-231   
4cwsHuman HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor
92 9-231   
4cwrHuman HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor
92 9-231   
4cwqHuman HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor
92 9-231   
4cwpHuman HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor
92 9-231   
4cwoHuman HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor
92 9-231   
4cwnHuman HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor
92 9-231   
4cwfHuman HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor
92 9-231   
4bqjstructure of HSP90 with an inhibitor bound
92 9-231   
4bqgstructure of HSP90 with an inhibitor bound
92 9-231   
4b7pStructure of HSP90 with NMS-E973 inhibitor bound
92 9-231   
1yetGELDANAMYCIN BOUND TO THE HSP90 GELDANAMYCIN-BINDING DOMAIN
91 9-231   
1yesHUMAN HSP90 GELDANAMYCIN-BINDING DOMAIN, ""OPEN"" CONFORMATION
91 9-231   
1yerHUMAN HSP90 GELDANAMYCIN-BINDING DOMAIN, ""CLOSED"" CONFORMATION
91 9-231   
1byqHSP90 N-TERMINAL DOMAIN BOUND TO ADP-MG
91 9-231   
2xjgStructure of HSP90 with small molecule inhibitor bound
91 9-231   
2xhxSTRUCTURE OF HSP90 WITH SMALL MOLECULE INHIBITOR BOUND
91 9-231   
2yejHSP90 INHIBITORS AND DRUGS FROM FRAGMENT AND VIRTUAL SCREENING
91 9-231   
2yeiHSP90 INHIBITORS AND DRUGS FROM FRAGMENT AND VIRTUAL SCREENING
91 9-231   
2ye8HSP90 INHIBITORS AND DRUGS FROM FRAGMENT AND VIRTUAL SCREENING
91 9-231   
2ye7HSP90 INHIBITORS AND DRUGS FROM FRAGMENT AND VIRTUAL SCREENING
91 9-231   
2xjjStructure of HSP90 with small molecule inhibitor bound
91 9-231   
2yeeHSP90 INHIBITORS AND DRUGS FROM FRAGMENT AND VIRTUAL SCREENING
91 9-231   
3rlrCo-crystal structure of the HSP90 ATP binding domain in complex with 4-(2,4-dichloro-5-methoxyphenyl)-2,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
92 9-24   
3rlqCo-crystal structure of the HSP90 ATP binding domain in complex with 4-(2,4-dichloro-5-methoxyphenyl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine-5- carbonitrile
92 9-222   
3rlpCo-crystal structure of the HSP90 ATP binding domain in complex with 4-(2,4-dichloro-5-methoxyphenyl)-6-methylpyrimidin-2-amine
92 9-222   
3r4pOptimization of potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitors of heat shock protein 90. identification of development candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide
92 9-222   
3r4oOptimization of Potent, Selective, and Orally Bioavailable Pyrrolodinopyrimidine-containing Inhibitors of Heat Shock Protein 90. Identification of Development Candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide
92 9-222   
3r4nOptimization of Potent, Selective, and Orally Bioavailable Pyrrolodinopyrimidine-containing Inhibitors of Heat Shock Protein 90. Identification of Development Candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide
92 9-222   
3k99HSP90 N-terminal domain in complex with 4-(1,3-dihydro-2H-isoindol-2-ylcarbonyl)benzene-1,3-diol
92 9-222   
3k98HSP90 N-terminal domain in complex with (1R)-2-(5-chloro-2,4-dihydroxybenzoyl)-N-ethylisoindoline-1-carboxamide
92 9-222   
3hekHSP90 N-terminal domain in complex with 1-{4-[(2R)-1-(5-chloro-2,4-dihydroxybenzoyl)pyrrolidin-2-yl]benzyl}-3,3-difluoropyrrolidinium
92 9-222   
3ekrDihydroxylphenyl amides as inhibitors of the Hsp90 molecular chaperone
92 9-222   
3ekoDihydroxylphenyl amides as inhibitors of the Hsp90 molecular chaperone
92 9-222   
2xduStructure of HSP90 with small molecule inhibitor bound
92 9-219   
1osfHuman Hsp90 in complex with 17-desmethoxy-17-N,N-Dimethylaminoethylamino-Geldanamycin
92 9-218   
2jjcHSP90 ALPHA ATPASE DOMAIN WITH BOUND SMALL MOLECULE FRAGMENT
92 9-218   
2k5bHuman CDC37-HSP90 docking model based on NMR
92 9-218   
4lwhCrystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ5
92 11-219   
3tuhCrystal Structure of the N-terminal domain of an HSP90 in the presence of an the inhibitor ganetespib
92 11-219   
4lwiCrystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ6
92 12-219   
4lwgCrystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ4
92 12-219   
4lwfCrystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ3
92 12-219   
4lweCrystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ2
92 12-219   
2qg0HSP90 complexed with A943037
92 12-218   
2qfoHSP90 complexed with A143571 and A516383
92 12-218   
3owdCrystal Structure of HSP90 with N-Aryl-benzimidazolone II
92 12-218   
3owbCrystal Structure of HSP90 with VER-49009
92 12-218   
3ow6Crystal Structure of HSP90 with N-Aryl-benzimidazolone I
92 12-218   
2qg2HSP90 complexed with A917985
92 12-218   
2qf6HSP90 complexed with A56322
92 12-218   
2ykjTRICYCLIC SERIES OF HSP90 INHIBITORS
91 11-218   
2ykiTRICYCLIC SERIES OF HSP90 INHIBITORS
91 11-218   
2ykeTRICYCLIC SERIES OF HSP90 INHIBITORS
91 11-218   
2ykcTRICYCLIC SERIES OF HSP90 INHIBITORS
91 11-218   
2ykbTRICYCLIC SERIES OF HSP90 INHIBITORS
91 11-218   
2yk9TRICYCLIC SERIES OF HSP90 INHIBITORS
91 11-218   
2yk2TRICYCLIC SERIES OF HSP90 INHIBITORS
91 11-218   
2yjxTRICYCLIC SERIES OF HSP90 INHIBITORS
91 11-218   
2yjwTRICYCLIC SERIES OF HSP90 INHIBITORS
91 11-218   

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