Query Result:

Summary: help

Your query was: P35991    
1
659

Domain annotation: [ InterPro ]

Colors:    Query |  Sequence |  Structures |  Models  |  Domains   |    

P35991 BTK_MOUSE ; Tyrosine-protein kinase BTK; EC=2.7.10.2; Agammaglobulinaemia tyrosine kinase; ATK; B-cell progenitor kinase; BPK; Bruton tyrosine kinase; Kinase EMB; Mus musculus (Mouse).

  

Models:

Model
 
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Templates
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%Seq id
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Sel.
[Show] reliability_1
SWISSMODEL
SC 3ocsA
99% 395 657
[Show] reliability_1
SWISSMODEL
SC 1btkB
99% 2 170
[Show] reliability_1
SWISSMODEL
SC 2ge9A
98% 270 387
[Show] reliability_1
SWISSMODEL
SC 1qlyA
97% 216 273
[Show] reliability_3
MODBASE
SC 2knoA
25% 266 378
[Show] reliability_1
MODBASE
SC 1k2pA
99% 397 654
[Show] reliability_3
NYSGXRC
TC 3comA
30% 405 598
[Show] reliability_3
NYSGXRC
TC 3ckxA
18% 399 650

Experimental Structures:

PDB Description %Seq Id from - to Sel.
4otrCrystal structure of BTK kinase domain complexed with 6-cyclopropyl-2-[3-[5-[[5-(4-ethylpiperazin-1-yl)-2-pyridyl]amino]-1-methyl-6-oxo-3-pyridyl]-2-(hydroxymethyl)phenyl]-8-fluoro-isoquinolin-1-one
97 378-659   
4otqCrystal structure of BTK kinase domain complexed with 1-[5-[3-(7-tert-butyl-4-oxo-quinazolin-3-yl)-2-methyl-phenyl]-1-methyl-2-oxo-3-pyridyl]-3-methyl-urea
97 378-659   
4ot6Crystal structure of BTK kinase domain complexed with 4-Methanesulfonyl-N-(3-{8-[4-(morpholine-4-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide
97 378-659   
4ot5Crystal structure of BTK kinase domain complexed with 4-tert-Butyl-N-(3-{8-[4-(4-methyl-piperazine-1-carbonyl)-phenylamino]-imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide
97 378-659   
3genThe 1.6 A crystal structure of human bruton's tyrosine kinase bound to a pyrrolopyrimidine-containing compound
98 381-659   
3k54Structures of human Bruton's tyrosine kinase in active and inactive conformations suggests a mechanism of activation for TEC family kinases.
98 381-659   
3pj3Crystal structure of BTK kinase domain complexed with 2-Methyl-5-[(E)-(3-phenyl-acryloyl)amino]-N-(2-phenyl-3H-imidazo[4,5-b]pyridin-6-yl)-benzamide
98 386-659   
3pj2Crystal structure of BTK kinase domain complexed with 2-[4-(2-Diethylamino-ethoxy)-phenylamino]-6-(4-fluoro-phenoxy)-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one
98 386-659   
3pj1Crystal structure of BTK kinase domain complexed with 3-(2,6-Dichloro-phenyl)-7-[4-(2-diethylamino-ethoxy)-phenylamino]-1-methyl-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one
98 386-659   
3pizCrystal structure of BTK kinase domain complexed with (5-Amino-1-o-tolyl-1H-pyrazol-4-yl)-[3-(1-methanesulfonyl-piperidin-4-yl)-phenyl]-methanone
98 386-659   
3piyCrystal structure of BTK kinase domain complexed with R406
98 386-659   
3pixCrystal structure of BTK kinase domain complexed with 2-Isopropyl-7-(4-methyl-piperazin-1-yl)-4-(5-methyl-2H-pyrazol-3-ylamino)-2H-phthalazin-1-one
98 386-659   
3p08Crystal structure of the human BTK kinase domain
98 393-659   
3ocsCrystal structure of bruton's tyrosine kinase in complex with inhibitor CGI1746
98 393-657   
3octCrystal structure of bruton's tyrosine kinase mutant V555R in complex with dasatinib
98 393-656   
1k2pCrystal structure of Bruton's tyrosine kinase domain
98 397-659   
4nwmCrystal structure of Bruton agammaglobulinemia tyrosine kinase complexed with BMS-809959 aka 4-tert-butyl-n-[2-me thyl-3-(6-{[4-(morpholine-4-carbonyl)phenyl]amino}-9h- purin-2-yl)phenyl]benzamide
98 396-657   
2z0pCrystal structure of PH domain of Bruton's tyrosine kinase
99 2-170   
1b55PH DOMAIN FROM BRUTON'S TYROSINE KINASE IN COMPLEX WITH INOSITOL 1,3,4,5-TETRAKISPHOSPHATE
99 2-170   
1bwnPH DOMAIN AND BTK MOTIF FROM BRUTON'S TYROSINE KINASE MUTANT E41K IN COMPLEX WITH INS(1,3,4,5)P4
98 2-170   
1btkPH DOMAIN AND BTK MOTIF FROM BRUTON'S TYROSINE KINASE MUTANT R28C
98 2-170   
2ge9Solution Structures of the SH2 domain of Bruton's Tyrosine Kinase
97 269-387   

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